A greater reduction in mortality has been observed with bariatric surgery than with GLP-1 RAs

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Bariatric metabolic surgery (BMS) is associated with greater mortality reduction than treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RA) in adults with diabetes duration of 10 years or less, study shows published online June 7 JAMA network opened.

Dror Dicker, MD, of Rabin Medical Center in Petah Tikva, Israel, and colleagues compared all-cause mortality and nonfatal major cardiovascular events associated with BMS versus GLP-1 RAs for adults with obesity and diabetes and no known cardiovascular disease. vascular disease in an observational study. retrospective cohort study. Data were included from 6,070 participants aged 24 years or older. The study included 3,035 matched pairs of patients who underwent BMS or received GLP-1 RAs, followed for a median of 6.8 years.

The researchers found that mortality was lower in those who underwent BMS than in those who received GLP-1 RA treatment (hazard ratio, 0.38) among 2,371 pairs of patients with diabetes duration of 10 years or less. When weight loss during the follow-up period was also included in the model, the association became non-significant.

No survival benefit was demonstrated for BMS over GLP-1 RAs in 664 patients with diabetes duration greater than 10 years. No significant difference was noted between groups in the risk of non-fatal major adverse cardiovascular events.

“The survival benefit associated with BMS compared to treatment with GLP-1 RAs can be explained by the greater relative reduction in body mass index observed in patients undergoing BMS (-31.4%) compared to that achieved in patients treated with GLP- 1 RAs (−12.8%),” the authors write.

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One author revealed ties to Novo Nordisk, Eli Lilly and Boehringer Ingelheim.

More information:
Dror Dicker et al, Bariatric metabolic surgery versus glucagon-like peptide-1 receptor agonists and mortality, JAMA network opened (2024). DOI: 10.1001/jamanetworkopen.2024.15392

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Quote: Greater reduction in mortality seen with bariatric surgery than GLP-1 RAs (2024, June 10), retrieved June 10, 2024 from https://medicalxpress.com/news/2024-06-greater-reduction-mortality-bariatric-surgery .html

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